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Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Surveillance, Second Edition, by Shayne C. Gad
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Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. These effects often present a hazard—particularly in individuals with compromised or limited organ system functions.
Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Surveillance, Second Edition covers safety pharmacology from the regulatory requirements down to the studies that must be done to justify them. Using the author’s more than 30 years of direct experience, the book incorporates tricks and practical insights for making studies work and understanding why they fail.
The second edition includes current regulations, including USFDA and those from Europe and Japan. Presenting a clear description of what is needed and why for supporting drug development, the book focuses on updated test methods, interpretation, and science. It covers the core and supplemental batteries of test procedures and how to do them and provides an overview of available facilities and contract organizations for performing studies.
- Sales Rank: #2838872 in eBooks
- Published on: 2012-04-26
- Released on: 2012-04-26
- Format: Kindle eBook
Review
[This] is the first book ever describing the specialty 'Safety Pharmacology' and it is a major contribution to understanding the increasing and demanding step from testing in animals to testing in humans. … Gad's book is an excellent summary of the ideas on the way to deal with safety pharmacology tests in drug development processes. It gives a good overview of ideas and testing strategies combined with many examples. … I can highly recommend reading the book … . It would make an admirable primer for safety pharmacologists, toxicologists, and people engaged with preclinical testing.
- BTS Newsletter
About the Author
Shayne Cox Gad is Principal at Gad Consulting Services in Cary, North Carolina. He has over 33 years experience as a toxicologist, statistical consultant, manager, and consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries.
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pharmaceutical bases and it,s development
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